2018 was a year of uncertainty due to political and economic developments in Mexico and abroad. Although the dust has somewhat settled and with a new government for the next six years, the healthcare sector still has only an idea of the policies to be implemented. This chapter will analyze healthcare sector's challenges and how it is preparing for them, including subpar government health spending, a rise in chronic conditions and high out-of-pocket expenditure from the point of view of governments, organizations and international bodies.